Jointly presented by The Huntington and Carnegie Observatories, this conference marks the centennial of the completion of the 100-inch Hooker telescope on Mount Wilson, which saw "first light" in November 1917 and heralded the dawn of modern astronomy. Historians, scientists, and others explore the influence of big telescopes, the significance of discoveries at Mount Wilson, the gendered nature of astronomy, and other related issues in the history of Southern California as an arena for space exploration.